Interpretable Deep Learning Reveals the Role of an E-box Motif in Suppressing Somatic Hypermutation of AGCT Motifs Within Human Immunoglobulin Variable Regions
Frontiers in Immunology（2024）
Key words
somatic hypermutation (SHM),activation induced deaminase (AID),immunoglobulin heavy chain,deep learning,integrated gradients,E-box transcription factors,E2A
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