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A RIPK1-specific PROTAC Degrader Achieves Potent Antitumor Activity by Enhancing Immunogenic Cell Death

Jonathan Mannion, Valentina Gifford,Benjamin Bellenie, Winnie Fernando,Laura Ramos Garcia,Rebecca Wilson,Sidonie Wicky John, Savita Udainiya,Emmanuel C. Patin,Crescens Tiu, Angel Smith, Maria Goicoechea,Andrew Craxton, Nathalia Moraes de Vasconcelos,Kwai-Ming J. Cheung, Nicholas J. Cundy,Olivier Pierrat,Alfie Brennan,Graeme Benstead-Hume,Theodoros I. Roumeliotis,John Alexander,Gareth Muirhead,Scott Layzell, Wenxin Lyu,Victoria Roulstone,Holly Baldock,Arnaud Legrand, Florian Gabel, Natalia Serrano-Aparicio,Chris Starling,Hongyan Guo,Jason Upton,Mads Gyrd-Hansen,Benedict Seddon,Ioannis Roxanis,Kevin Harrington,Syed Haider,Jyoti S. Choudhary, Swen Haider,Tencho Tenev,Pascal Meier

Immunity（2024）

Cited 5|Views25
Key words
RIPK1,cell death,necroptosis,inflammation,anticancer immunity,TNF,interferon,immunotherapy,TLR3,radiotherapy
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