99m Tc-3P-RGD2 molecular imaging targeting integrin α v β 3 in head and neck squamous cancer xenograft

99m Tc-3P-RGD2 and SPECT/CT were valuable tools for selecting patient likely benefit from integrin α v β 3 blocking therapy. To evaluate the feasibility of 99m Tc-3P-RGD2 imaging to detect head and neck squamous cell carcinoma, 99m Tc-3P-RGD2 was prepared and the relationship between its accumulation and integrin α v β 3 expression in nude mice bearing HEP-2 or CNE-1 carcinoma xenograft were analyzed. This study demonstrated that 99m Tc-3P-RGD2, with high affinity to integrin α v β 3 , will provide basis for α v β 3 involved individual therapy.