Regeneration at the interface of mental and physical health after trauma

Trauma, both psychological and physical, represents a complex and pervasive challenge to individual well-being. This paper explores the dynamic interplay between mental and physical health in the context of trauma, shedding light on the processes of regeneration that occur at their interface. Drawing from a comprehensive review of basic, clinical and interdisciplinary research, this paper elucidates the bidirectional relationships between mental and physical health outcomes following traumatic experiences. Especially the influence of inflammation, gut microbiome, stress hormones and the activation of the HPA axis are explored in more detail. In conclusion, stress-related disorders and mental diseases should be taken into account when patients display a disturbed healing after physical injury. Awareness for the significant impact of mental health on trauma outcome should be increased among physicians.