Regioselective synthesis of spiro quinazolinones via sequential hydroalkoxylation and intramolecular amide-cyclization of alkynol ureas

A TfOH-mediated, metal-free protocol for the synthesis of spiro-furan/pyran quinazolinones through a cascade hydroalkoxylation and intramolecular amide-cyclization reaction of alkynol ureas has been unveiled. This methodology facilitates the generation of...