FIGURE 2 from Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast Cancer

The effects of PDXs on plasma miR-486 and functional markers in skeletal muscle. A, A significant decline in circulating miR-486 levels was observed across all PDX subtypes. B, Differential effects of PDX subtypes on miR-486 in skeletal muscles of mice. C, Differential impact of PDXs on skeletal muscle Pax7. D, Differential impact of PDXs on skeletal muscle MyoD. E, The effect of PDXs on skeletal muscle Myh1. F, The effect of PDXs on skeletal muscle p53. G, ER+/PR+ and ER+/PR− tumor-derived PDXs increased skeletal muscle Pdk4, compared with TNBC PDXs.