Predicting Prognosis of Phyllodes Tumours using a Mammography- and Magnetic Resonance Imaging-based Radiomics Model: A Preliminary Study

Purpose To investigate whether a radiomics model based on mammography (MG) and magnetic resonance imaging (MRI) can be used to predict disease-free survival (DFS) after phyllodes tumour (PT) surgery. Method 131 PT patients who underwent MG and MRI before surgery between January 2010 and December 2020 were retrospectively enrolled, including 15 patients with recurrence and metastasis and 116 without recurrence. 884 and 3138 radiomic features were extracted from MG and MR images, respectively. Then, multiple radiomics models were established to predict the recurrence risk of the patients by applying a support vector machine classifier. The area under the ROC curve (AUC) was calculated to evaluate model performance. After dividing the patients into high- and low-risk groups based on the predicted radiomics scores, survival analysis was conducted to compare differences between the groups. Results In total, 3 MG-related and 5 MRI-related radiomic models were established; the prediction performance of the T1WI feature fusion model was the best, with an AUC value of 0.93. After combining the features of MG and MRI, the AUC increased to 0.95. Furthermore, the MG, MRI and all-image radiomic models had statistically significant differences in survival between the high- and low-risk groups (P<0.001). All-image radiomics model showed higher survival performance than the MG and MRI radiomics models alone. Conclusions Radiomics features based on preoperative MG and MR images can predict DFS after PT surgery, and the prediction score of the image radiomics model can be used as a potential indicator of recurrence risk. Microabstract To investigate whether a radiomics model based on mammography (MG) and magnetic resonance imaging (MRI) can be used to predict disease-free survival (DFS) after phyllodes tumour (PT) surgery, we retrospectively collected 131 patients for the study. The fusion radiomics model of MG and MRI yielded significantly higher AUC value of 0.95 than the MG and MRI radiomics models alone. This study reveals the potential value of radiomics in evaluating the prognosis of PT.