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Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib

Robert D. Franklin, Travis Armiger, Douglas A. L. Otte,Reed T. Larson,Glenn Spencer, Pratiq A. Patel, Mellie June Paulines, Jackson R. Hall, Kai-Jiong Xiao,Patrick S. Fier, Vailankanni L. Rodrigues,Erik D. Guetschow,Nadine Kuhl, Lisa Jellett, James Corry,Cheol K. Chung,David A. Thaisrivongs

Organic Process Research & Development（2024）

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