Photocatalytic redox-neutral -C(sp³)-H pyridination of glycine derivatives and N-arylamines with cyanopyridines

A photo-induced alpha-C(sp(3))-H decyanative pyridination of N-arylglycine derivatives with cyanopyridines was developed. This reaction was performed under organic photocatalytic and redox-neutral conditions via a radical-radical cross-coupling process. Besides, the protocol was also suitable for the C(sp(3))-H pyridination of N-aryl tetrahydroisoquinolines as well as benzylamines.