The mutual regulation between æ T cells and macrophages during wound healing

Macrophages are the main cells shaping the local microenvironment during wound healing. As the prime T cells in the skin, gamma delta T cells participate in regulating microenvironment construction, determining their mutual regulation helps to understand the mechanisms of wound healing, and explore innovative therapeutic options for wound repair. This review introduced their respective role in wound healing firstly, and then summarized the regulatory effect of gamma delta T cells on macrophages, including chemotaxis, polarization, apoptosis, and pyroptosis. Last, the retrograde regulation on gamma delta T cells by macrophages was also discussed. The main purpose is to excavate novel interventions for treating wound and provide new thought for further research. gamma delta T cells influence macrophages polarization via secreting IFN-gamma, IL-17, IL-10, and IL-4, and regulate macrophage apoptosis and pyroptosis with Fas-FasL, perforin/granzyme, and TCR or inflammation promotion.