Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants.

André B P van Kuilenburg, Marjolein C H Pleunis-van Empel, Rick B Brouwer, Angelique E J Sijben, Daan G Knapen, Thijs H Oude Munnink,Jelmer J van Zanden, Jenny Janssens-Puister,Doreen Dobritzsch,Rutger Meinsma, Judith Meijer-Jansen, Silvy J M van Dooren,Raymon Vijzelaar, Ana Pop,Gajja S Salomons, Jan Gerard Maring,Klary E Niezen-Koning

JCO precision oncology（2024）

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摘要

A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.

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