Gold Nanoparticles Decorated Chitosan-Agarose Modified Magnetic Nanocomposite: Catalytic Application for the Preparation of Tetrazoles and Biological Evaluation for the Treatment of Lung Carcinoma

This article describes a new type of core–shell pattern Fe3O4 nanoparticle (Au/CS-agar@Fe3O4) that was developed using Au NPs and chitosan-agarose composite. Our goal in catalytic exploration was to synthesize 5-substituted-1H-tetrazoles via click synthesis using aryl halides. By this method, using K4[Fe(CN)6] as a nontoxic CN resource, we treated a variety of aryl halides (Cl, Br, and I) using the highly effective and reusable Au/CS-agar@Fe3O4 catalyst, catalyzing the [3 + 2]-cycloaddition of the corresponding aryl nitriles with NaN3 to the successive one-pot solvent-free preparation at 120 °C of 5-substituted-1H-tetrazoles. The various substrates provided a yield in the range of 70–96