Antitrypanosomal activity of new alkoxyhydroperoxides formed by cycloaddition of ozone into allyl moiety of eugenol

Eugenol, a natural phenylpropanoid found in several plants, was exposed to ozone atmosphere to afford three new alkoxyhydroperoxides and prevised homovanillin. The effect of these compounds against the protozoan parasite Trypanosoma cruzi resulted in EC50 values ranging from 7.4 to 10.5 μM, superior to the standard drug benznidazole (EC50 = 18.7 μM). Based on these results, it is possible to consider these compounds as scaffolds for the development of new drug candidates against Chagas disease.