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Synthetic Process Development of (R)-(+)-1,2-epoxy-5-hexene: an Important Chiral Building Block

Daryl Guthrie,John M. Saathoff, Rajkumar Lalji Sahani, Aline Nunes De Souza,Daniel W. Cook, Samuel R. Hochstetler,Justina M. Burns, Roudabeh Sadat Moazeni-Pourasil, Janie Wierzbicki,Saeed Ahmad, G. Michael Laidlaw,B. Frank Gupton,Charles S. Shanahan,Douglas A. Klumpp,Limei Jin

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2024）

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Key words
lenacapavir,epoxide,chiral resolution,epichlorohydrin,DOE,process development,scalable
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