Switching from gem-difluorovinylation to carboxylation: Ligand-enabled palladium-catalyzed Heck annulation of alkene-tethered aryl halides with sodium difluorochloroacetate

Reported herein is the use of ligand to tune palladium-catalyzed intramolecular Heck gem-difluorovinylation and carboxylation with alkene-tethered aryl halides, which provides an efficient avenue for building indolo[2,1-a]isoquinoline skeletons. The sodium...