Terpenes and polyketides from the marine‐derived fungus Penicillium sp. OPR23‐FS02 with cytotoxic and antimicrobial effects

AbstractChemical study of the fermentation culture of the marine‐derived fungal strain Penicillium sp. OPR23‐FS02 led to isolation of ten secondary metabolites, including two terpenes, purpuride (1) and penioxalicin (2) and eight polyketides, trans‐3,4‐dihydro‐3,4,8‐trihydroxynaphthalen‐1(2H)‐one (3), chloromonilinic acid B (4), chrysophanol (5), emodin (6), ω‐hydroxyemodin (7), questin (8), endocrocin (9), and ergochrome F (10). Their structures were elucidated by analyzing their NMR and HRESI mass spectra and comparing with the literature data. Compound 9 was weakly cytotoxic against HepG2 cell line, with an IC50 value of 89.86 ± 2.63 µm. Compounds 4 and 10 showed antimicrobial effect against Enterococcus faecalis whereas 6 inhibited Bacillus cereus growth, with the same MIC values of 64 µm.