Oxidative stress and ovarian aging: from cellular mechanisms to diagnostics and treatment

The December ESHRE Journal Club discussion focused on a study by , the cellular and molecular implications of oxidative stress on oocyte aging, the factors that impair oocyte quality besides age, and the potential therapeutic strategies to mitigate oxidative stress and mitochondrial dysfunction in oocytes of advanced maternal age. AMA, advanced maternal age; GV, germinal vesicle oocyte; MI, metaphase I oocyte; ROS, reactive oxygen species; TCA, tricarboxylic acid cycle.