Circulating progenitor cells and coronary collaterals in chronic Total occlusion
International Journal of Cardiology(2024)
摘要
Background
The role of circulating progenitor cells (CPC) in collateral formation that occurs in the presence of chronic total occlusions (CTO) of a coronary artery is not well established. In stable patients with a CTO, we investigated whether CPC levels are associated with (a) collateral development and (b) ischemic burden, as measured by circulating high sensitivity troponin-I (hsTn-I) levels.
Methods
CPCs were enumerated by flow cytometry as CD45med+ blood mononuclear cells expressing CD34 and both CD34 and CD133 epitopes. The association between CPC counts and both Rentrop collateral grade (0, 1, 2, or 3) and hsTn-I levels were evaluated using multivariate regression analysis, after adjusting for demographic and clinical characteristics.
Results
In 89 patients (age 65.5, 72% male, 27% Black), a higher CPC count was positively associated with a higher Rentrop collateral grade; [CD34+ adjusted odds ratio (OR) 1.49 95% confidence interval (CI) (0.95, 2.34) P = 0.082] and [CD34+/CD133+ OR 1.57 95% CI (1.05, 2.36) P = 0.028]. Every doubling of CPC counts was also associated with lower hsTn-I levels [CD34+ β −0.39 95% CI (−0.54, −0.18) P = 0.001] and [CD34+/CD133+ β −0.32 95% CI (−0.47, −0.12) P = 0.003] after adjustment.
Conclusion
Individuals with higher CPC counts have greater collateral development and lower ischemic burden in the presence of a CTO.
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关键词
Chronic Total occlusion,Circulating progenitor cell,Collaterals
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