Revisiting natural deep eutectic solvents (nades) as extraction media and ready-to-use purposes

The assessment of efficient and sustainable methods for extracting high-value compounds from natural products aligns with some of the statements proposed by the 12 Principles of Green Chemistry and 17 Sustainable Development Goals. Replacing hazardous chemicals with safer alternatives, such as Natural Deep Eutectic Solvents (NADES), offers a promising and environmentally friendly approach. This review provides a comprehensive analysis of the composition of NADES, associated extraction techniques, and advancements in their use as an extraction media for bioactive compounds from their first report in 2013 until 2023. Moreover, an in-depth discussion of the terminology of NADES is presented and an updated and new term is suggested for specific combinations: Mixtures based on Natural Compounds (MINACs). Finally, prospective applications of such solvents are provided, complemented by insights into emerging trends and their potential to produce ready-to-use extracts.