Chimeric Antigen Receptor T-Cell Therapy for Refractory Post-transplant Lymphoproliferative Disorder after Lung Transplantation

Chimeric antigen receptor T-cell therapy (CAR-T) has been used to treat refractory post-transplant lymphoproliferative disorder (PTLD) in solid organ transplant patients, including heart, kidney, liver, intestine, and pancreas. We report the use of CAR-T for treating refractory PTLD in a 73-year-old female who was 7 years post bilateral lung transplantation for idiopathic pulmonary fibrosis (IPF). We discuss the immunosuppression management in this patient, as well as her clinical course and outcome.