Development and Optimization of Eperisone Hydrochloride Microcapsule

The main objective of the work is to develop the microcapsule of eperisone hydrochloride. In the investigation, a 23-factorial design were was employed for the optimization process and to investigate the effect of Eudragit® RS100 concentration in the coating solution (X1), the speed of rotation (X2) and the concentration of plasticizer (PEG 400) (X3) on the release rate of the drug from the microcapsules. The extent of coating (Y1), and the percentage of drug released at 1 (Y2), 6 (Y3) and 12 hours (Y4) were selected as dependent variables. Optimized microcapsules of eperisone hydrochloride follow the zero-order kinetics that a promising controlled release of the highly water soluble drug and was successfully designed for further formulation.