Racial/Ethnic Disparities: Discrimination’s Impact on Health-Related Quality of Life—An All of Us Cancer Survivors’ Cross-sectional Study

Discrimination is associated with worse mental and physical health outcomes. However, the associations among cancer survivors are limited. We examined whether discrimination is associated with HRQoL and whether adjusting for it reduces racial/ethnic disparities in HRQoL among cancer survivors. Cross-sectional data from adult cancer survivors who completed surveys on discrimination in the medical settings (DMS), everyday perceived discrimination (PD), and HRQoL in the “All of Us” Program from 2018 to 2022 were assessed. We created a binary indicator for fair-to-poor vs. good-to-excellent physical health and mental health. PD and DMS scores were a continuous measure with higher scores reflecting more discrimination. Multivariable logistic regression models tested whether DMS and PD are associated with HRQoL and whether they differently affect the association between race/ethnicity and HRQoL. The sample (N = 16,664) of cancer survivors was predominantly White (86