0525 Can Intra Oral and Facial Photos Predict Obstructive Sleep Apnea in the General and Clinical Population ?

Abstract Introduction Obstructive sleep apnea (OSA) is associated with upper airway soft tissue and craniofacial skeletal alterations, but if these abnormalities, using quantitative facial and intraoral photographic analysis, differ between in the general population and clinical samples were not tested yet. This study aimed to evaluate and compare measurements of standardized craniofacial and intraoral photographs between clinical and general population samples, between groups of individuals with an apnea-hypopnea index (AHI) ≥15 and AHI< 15, and the interaction between them, as well as the relationship with the presence and severity of OSA. Methods We used data from 929 participants from Sleep Apnea Global Interdisciplinary Consortium (SAGIC): 309 patients from a clinical setting and 620 volunteers from a general population sample. Results Moderate and severe OSA (AHI≥15) were observed in 30.3% of the total sample and there were some interactions between facial/intraoral measures with OSA and both samples. Mandibular volume (p< 0.01), sternomental distance (p=0.04), and lateral face height (p=0.04) were higher in the AHI≥15 group in the clinical sample compared to the AHI≥15 group in the general population and AHI< 15 group in the clinical sample. Multivariate regression suggests photography-based variables capture independent associations with OSA in both samples. When adjusted for sex and age, greater mandible width (p< 0.01) differed both in the clinical and in the general population samples, reflecting AHI severity and the likelihood of OSA; the measure of smaller tongue curvature (p< 0.01) reflected the severity and probability of OSA in the clinical sample; and the higher posterior mandibular height (p=0.04) showed a relationship with higher AHI and higher risk of moderate to severe OSA in the general population sample. However, when adjusted for sex, age, and BMI, only smaller tongue curvature (p< 0.01) was associated with moderate/severe OSA. Conclusion Quantitative standardized facial photographs indicated that the measures of greater tongue and mandible were associated with increased OSA risk in the clinical sample and higher facial height measurement was associated in the general population sample. Support (if any) Acknowledgments: AFIP, CNPq, CAPES, and SAGIC group.