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Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles

Salma M. Hefny,Tarek F. El-Moselhy,Nabaweya El-Din,Simone Giovannuzzi,Thamer Bin Traiki,Mansoor-Ali Vaali-Mohammed, Ahmed M. El-Dessouki,Koki Yamaguchi,Masaharu Sugiura, Moataz A. Shaldam,Claudiu T. Supuran,Maha-Hamadien Abdulla,Wagdy M. Eldehna,Haytham O. Tawfik

Journal of Medicinal Chemistry（2024）

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