Single Cell Atlas: a single-cell multi-omics human cell encyclopedia
Genome Biology(2024)
摘要
Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two bulk omics across 125 healthy adult and fetal tissues. We construct its complement web-based platform, the Single Cell Atlas (SCA, www.singlecellatlas.org ), to enable vast interactive data exploration of deep multi-omics signatures across human fetal and adult tissues. The atlas resources and database queries aspire to serve as a one-stop, comprehensive, and time-effective resource for various omics studies.
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关键词
Single-cell omics,Multi-omics,Single Cell Atlas,Human database,Single-cell RNA-sequencing,Spatial transcriptomics,Single-cell ATAC-sequencing,Single-cell immune profiling,Mass cytometry,Flow cytometry
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