Curcumin Mitigates Aβ33-42 Fibril-Induced Neuronal Injury in the Hippocampus

The targeted removal of Aβ33-42 accumulation in vivo emerges as a promising strategy for Alzheimer’s disease (AD) treatment, offering potential avenues for the development of innovative anti-AD therapeutics. In this study, the effect of curcumin (Cur) with AD therapeutic potential on the cellular mechanical properties of Aβ33-42 fibril-induced neurons injury in the hippocampus of mice has been explored. The results showed that Cur had no obvious toxicity and side effects on neuronal cells and could significantly inhibit Aβ33-42-induced cell damage and improve cell survival. The measurements of cell mechanical properties revealed that Cur could restore the mechanical properties of damaged cells to a large extent. In addition, the inhibition mechanism of Cur on Aβ33-42-induced damage cell model was explained, which provides clues for the development of new drugs for the AD treatment.