Associations of granulocyte colony-stimulating factor with toxicities and efficacy of chimeric antigen receptor T-cell therapy in relapsed or refractory B-cell acute lymphoblastic leukemia

Sha Ma, Ying Wang,Kunming Qi, Wenyi Lu,Yuekun Qi, Jiang Cao,Mingshan Niu, Depeng Li,Wei Sang, Zhiling Yan,Feng Zhu, Hai Cheng,Zhenyu Li, Mingfeng Zhao,Kailin Xu

Cancer Immunology, Immunotherapy（2024）

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摘要

Few studies have reported the associations of granulocyte colony-stimulating factor (G-CSF) with cytokine release syndrome (CRS), neurotoxic events (NEs) and efficacy after chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). We present a retrospective study of 67 patients with R/R B-ALL who received anti-CD19 CAR T-cell therapy, 41 (61.2

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B-cell acute lymphoblastic leukemia,Chimeric antigen receptor T-cell therapy,Granulocyte colony-stimulating factor,Cytokine release syndrome,Neurotoxic events,Efficacy

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