Evolution of the Clinical-Stage Hyperactive TcBuster Transposase As a Platform for Robust Non-Viral Production of Adoptive Cellular Therapies

Joseph G. Skeate,Emily J. Pomeroy,Nicholas J. Slipek,Bryan J. Jones,Bryce J. Wick,Jae-Woong Chang,Walker S. Lahr, Erin M. Stelljes,Xiaobai Patrinostro,Blake Barnes,Trevor Zarecki,Joshua B. Krueger, Jacob E. Bridge,Gabrielle M. Robbins, Madeline D. McCormick, John R. Leerar, Kari T. Wenzel, Kathlyn M. Hornberger, Kirsti Walker, Dalton Smedley,David A. Largaespada,Neil Otto,Beau R. Webber,Branden S. Moriarity

MOLECULAR THERAPY（2024）

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关键词

Cellular Therapy Engineering,Immunotherapy,Transposons,NK cells,T cell,Chimeric Antigen Receptors,Engineering Pipeline,High-throughput mutant screening

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