Synthesis, Docking Studies, and Biological Evaluation of Some New Pyrrolyl Benzohydrazide Derivatives

A series of 16 new N-(2-(4-(1H-pyrrol-1-yl)phenoxy)acetyl)-N-substituted benzohydrazides was synthesized by the reaction of 1-(1H-pyrrol-1-yl)benzohydrazide with substituted benzoic acids in the presence of N,N-dimethylformamide, HBTU, and DIEA. Molecular docking and biological screening were done on the synthesized compounds to conduct antitubercular and antibacterial activity tests. The selected compounds were investigated for the inhibition of the InhA and DHFR enzymes. Promising antitubercular, antibacterial, and enzyme inhibitory action has been shown for all molecules. Absorption, distribution, metabolism, elimination, and toxicity investigations were also completed.. KEYWORDS :Antitubercular, Benzohydrazides, Docking, In silico, Pyrrole.