Patient factors associated with cancer worry post-breast reconstruction: a cross-sectional study

PURPOSE The BREAST-Q Breast Cancer module is a patient reported outcome measure for women with a breast cancer diagnosis. Our research team developed and validated a novel BREAST-Q scale for this module that measures quality of life outcomes specific to cancer worry. The aim of this study was to investigate patient breast reconstruction factors that are associated with worse scores on the new BREAST-Q Cancer Worry scale. METHODS Women with a history of breast cancer treated with mastectomy and reconstruction, aged ≥18 years, and English-speaking were recruited through the Love Research Army (LRA) between October-November 2019. Participants completed demographic and clinical questions alongside the BREAST-Q Cancer Worry scale. Univariable and multivariable regression analyses were used to identify participant characteristics associated with Cancer Worry scores. RESULTS Of 554 potential respondents, n=538 (97.1%) completed the Cancer Worry scale. The average patient age was 58.4 years (+9.8). Cancer Worry scores were normally distributed with a mean of 46.4 (+17.2). Cancer Worry scores were significantly associated (p<0.01) with younger age, history of radiation therapy, complications associated with breast surgery since diagnosis, use of textured breast implants, and shorter duration since surgery. CONCLUSION This exploratory analysis provides evidence of patient characteristics that may be associated with more cancer worry following post-mastectomy breast reconstruction.