Selective Anastasis Induction by Bee Venom in Normal Cells: A Promising Strategy for Breast Cancer Therapy with Minimal Impact on Normal Cell Viability

Sinan Tetikoglu,Muharrem AKCAN,Ugur UZUNER, Selcen CELIK UZUNER

crossref(2024)

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摘要
Abstract Anastasis is a phenomenon recently described as cellular escape from induced apoptosis. Although its mechanism has not yet been fully elucidated, anastasis is thought to play a role in the development of drug resistance in cancer cells. However, no significant regulation of anastasis has been discovered in normal and cancerous cells during anti-cancer therapy. What is expected from current cancer treatment strategies is the development of drugs that can selectively attack cancer cells without negatively affecting normal cell proliferation. Therefore, this study is the first to evaluate whether bee venom, a natural cytotoxic agent, has similar selectivity in producing an anastatic effect compared to the cytotoxic agent cisplatin. The study showed that bee venom was effective on inducing anastasis in normal cells (MCF10A, NIH3T3 and ARPE19), but on the process of irreversible cell death in breast cancer cells (MDA-MB-231 and MCF7). On the other hand, liver cancer cells (HEPG2) were moderately more resistant to permanent cell death caused by bee venom and tended to recover at higher concentrations compared to breast cancer cells. However, cisplatin treatment caused permanent non-selective cell death in both normal and cancerous cells. In addition, it was determined that the selectivity indices based on IC50 values of bee venom were higher than cisplatin. Taken together, bee venom is effective at selectively inducing anastasis only in normal cells rather than cancer cells; This suggests that bee venom has significant potential in selective cancer therapy, especially breast cancer, by promoting the recovery and maintenance of viability of normal cells.
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