Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures

Aaron D. Schwab,Todd A. Wyatt, Grace Moravec,Geoffrey M. Thiele,Amy J. Nelson,Angela Gleason, Oliver Schanze,Michael J. Duryee,Debra J. Romberger,Ted R. Mikuls,Jill A. Poole

Respiratory Research（2024）

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摘要

Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet their cellular role remains unclear. CCR2 RFP+ mice were intratracheally instilled with high concentration ODE (25

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关键词

Endotoxin,Organic dust,Immunology,Inflammation,Lung disease,Monocytes

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