Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk

Maria Stella de Biase,Florian Massip, Tzu-Ting Wei,Federico M. Giorgi,Rory Stark, Amanda Stone, Amy Gladwell, Martin O’Reilly, Daniel Schütte,Ines de Santiago,Kerstin B. Meyer,Florian Markowetz,Bruce A. J. Ponder,Robert C. Rintoul,Roland F. Schwarz

Genome Medicine（2024）

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摘要

Lung cancer is the leading cause of cancer-related death in the world. In contrast to many other cancers, a direct connection to modifiable lifestyle risk in the form of tobacco smoke has long been established. More than 50

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