Does nematic order allow groups of elongated cells to sense electric fields better?
arxiv(2024)
摘要
Collective response to external directional cues like electric fields plays a
pivotal role in processes such as tissue development, regeneration, and wound
healing. In this study we focus on the impact of anisotropy in cell shape and
local cell alignment on the collective response to electric fields. We model
elongated cells that have a different accuracy sensing the field depending on
their orientation with respect to the field. Elongated cells often line up with
their long axes in the same direction - "nematic order" - does this help the
group of cells sense the field more accurately? We use simulations of a simple
model to show that if cells orient themselves perpendicular to their average
velocity, alignment of a cell's long axis to its nearest neighbors' orientation
can enhance the directional response to electric fields. However, for cells to
benefit from aligning, their accuracy of sensing must be strongly dependent on
cell orientation. We also show that cell-cell adhesion modulates the accuracy
of cells in the group.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要