Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study

A knowledge gap exists in associating later life’s osteoporotic fracture and middle adulthood’s BMI trajectories. We observed an association showing those transitioning from overweight to normal weight face a higher fracture risk in late adulthood, emphasizing the potential benefits of maintaining a stable BMI to reduce late-life fractures. Numerous studies on the relationship between obesity and fractures have relied on body mass index (BMI) at a single time point, yielding inconclusive results. This study investigated the association of BMI trajectories over middle adulthood with fracture risk in late adulthood. This prospective cohort study analyzed 1772 qualified participants from the Framingham Original Cohort Study, with 292 (16.5