The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses

Susel Loli Quinteros,Nathaniel W. Snyder,Adam Chatoff, Fiona Ryan, Bronwyn O'Brien,Sheila Donnelly

EUROPEAN JOURNAL OF IMMUNOLOGY（2024）

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摘要

We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice. image

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关键词

FhHDM-1,Helminth therapy,Macrophage,Trained immunity,Type 1 diabetes

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