Optimization of fermentation conditions and medium components for chrysomycin a production by Streptomyces sp. 891-B6
BMC Microbiology(2024)
摘要
Chrysomycin A (CA) is a promising antibiotic for treatment of Gram-positive bacterial infections and cancers. In order to enhance CA yield, optimization of fermentation conditions and medium components was carried out on strain Streptomyces sp. 891-B6, an UV-induced mutant with improved CA titer compared with its wide-type marine strain 891. Using one-way experiment, the optimal fermentation conditions for CA production in 1-L shake flask were obtained as follows: 12 days of fermentation time, 5 days of seed age, 5
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关键词
Chrysomycin,Marine Streptomyces,Fermentation,Optimization,Single-factor experiment,Response surface methodology
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