The Effect of Citrus aurantium L. Flower Extract on the Severity of Primary Dysmenorrhea: A Double-Blind, Randomized, Controlled Clinical Trial

Purpose This study aimed to assess the effect of Citrus aurantium L. flower on the distance between two cycles, physical activity, days of bleeding, and intensity of dysmenorrhea (primary objectives), and complications of interventions or adverse effects (secondary purpose). Methods This double-blind, randomized controlled clinical trial was conducted on 105 girls (15-20 years old) with primary dysmenorrhea. In the intervention cycles, from the first to the third day, participants received 250 mg C. aurantium flower hydro-alcoholic extract capsule, Mefenamic acid (MA) capsule, or placebo three times a day based on the study groups. Results The results showed that the severity of dysmenorrhea in the groups consuming C. aurantium flower and MA was significantly lower than that before the intervention and compared to the placebo group (P<0.001), which this reduction in the severity of pain in the C. aurantium flower group was also significantly higher than that of the MA group (P<0.001) at the first and second days. Conclusion C. aurantium flower had higher efficacy and satisfaction rate and lower side effects in reducing the severity of primary dysmenorrhea compared to MA.