Denoising in optical coherence tomography volumes for improved 3D visualization.

Optical coherence tomography (OCT) has already become one of the most important diagnostic tools in different fields of medicine, as well as in various industrial applications. The most important characteristic of OCT is its high resolution, both in depth and the transverse direction. Together with the information on the tissue density, OCT offers highly precise information on tissue geometry. However, the detectability of small and low-intensity features in OCT scans is limited by the presence of speckle noise. In this paper we present a new volumetric method for noise removal in OCT volumes, which aims at improving the quality of rendered 3D volumes. In order to remove noise uniformly, while preserving important details, the proposed algorithm simultaneously observes the estimated amounts of noise and the sharpness measure, and iteratively enhances the volume until it reaches the required quality. We evaluate the proposed method using four quality measures as well as visually, by evaluating the visualization of OCT volumes on an auto-stereoscopic 3D screen. The results show that the proposed method outperforms reference methods both visually and in terms of objective measures.