Genetic haute couture to block HIV-1 at front doors

The chemokine receptors CCR5 and CXCR4 are “front doors” for HIV-1 infection in host cells, and their targeting represents a potential solution for a cure. Dudek et al.1 now propose a new gene editing strategy to simultaneously block CCR5- and CXCR4-mediated HIV-1 entry in autologous hematopoietic stem and progenitor cells (HSPCs).