Hepatic artery aneurysms in infective endocarditis: report of 10 cases and literature review.

Background Hepatic artery aneurysms (HAAs), albeit rare in infective endocarditis (IE), are associated with a life-threatening morbidity. Methods Retrospective review of 10 HAA-IE-patients based on a total of 623 IE-patients managed in two institutions (2008-2020) vs 35 literature’ cases. Results In our patient population, HAAs (10 males, mean-age 48) were incidentally found during IE-workup. All were asymptomatic. IE involved mitral (n=6), aortic (n=3), or mitral-aortic valve (n=1). Predisposing factors for IE were: prosthetic valve (n= 6), previous IE (n=2), IV drug user (n=1). Streptococcus spp were predominant (n=4), then staphylococcus spp (n=2) and E. faecalis (n=2).All patients presented associated lesions: infectious aneurysms (n=5), emboli (n=9), abscesses (n=5) and spondylitis/spondylodiscitis (n=2).HAA patterns on abdominal CT-Angiography (CTA) were solitary (70%), mean diameter 11.7mm (range 2-30), intrahepatic location (100%) involving the right HA in 9/10 (90%) patients. In 2 patients HAAs were complicated (rectorragia and hemobilia in 1, cholestasis in the other). Six patients underwent endovascular hepatic embolization (2 with multiple HAAs). Three HAA-IEs <15mm resolved under antibiotherapy on abdominal CTA follow-up. All patients underwent cardiac surgery. Late outcome was favorable in all followed patients (5/10).Literature review showed the preponderance of Streptococcus spp., of right lobe and intrahepatic HAA localization. Complications revealed HAAs in patients under antibiotic therapy and/or after cardiac surgery in 17 literature’ cases of delayed diagnosis. Conclusion Abdominal CTA was pivotal in the initial IE work-up. Small aneurysms (≤15mm) resolved under antibiotherapy. The usual treatment modality was HAA embolization and endovascular embolization prior to valve surgery was safe.