Figure S2 from Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis

Supplementary Figure S2: (A) Percentage of tumor-free mice in PyMT NE+/+ (N=30) and PyMT NE-/- (N=21) mice, between 12-14 weeks of age. (B) Total tumor mass, (C) number of glands with tumors per mouse and (D) doubling time of tumors at end point (12-14 weeks age) in PyMT NE+/+ & PyMT NE-/- mice. (E) Frequency of the major histologies (solid, alveolar/tubular, papillary, and adenosquamous) detected in both PyMT NE+/+ and PyMT NE-/- primary tumors. (F) Spontaneous tumors isolated from PyMT NE+/+ and PyMT NE-/- mice were implanted in FVB NE+/+ and FVB NE-/- respectively. Tumor growth curves, as a function of days post implantation are shown.