[ZeoDABCO-SO3H]Cl catalyzed synthesis, cytotoxicity against normal kidney cell line and molecular docking study of dihydropyrimidines-2-ones/thiones

In the present study, synthesis of material supported [ZeoDABCO-SO3H]Cl Bronsted acid heterogeneous catalyst was synthesized and investigated in the reaction between aryl aldehydes, ethyl acetoacetate, and urea/thiourea for the synthesis of Dihydro pyrimidines-2-ones/ thiones in excellent yields. The synthesized [ZeoDABCO-SO3H] Cl is reusable for six runs without suffering a significant loss of catalytic activity, according to reusability research. The existing technology has a variety of advantages, involving ambient reaction conditions, use of ethanol as green solvent, high yield, less time, and simple workup processes. Additionally, we have investigated the promising cytotoxicity against normal kidney cell lines, with the latter validated by a study of molecular docking.