Research Progress in Enantioselective Radical Desymmetrization Reactions

Enantioselective radical desymmetrization is a highly effective approach for rapidly creating enantioenriched molecules, introducing dramatically increased structural complexity from readily available prochiral or meso compound feedstocks. Two strategic modes have been developed for these reactions, which differ in the nature of the stereo-determining steps. The first category deals primarily with the stereoselective desymmetrization of closed-shell radical precursors or functional reagents, whereas the second category achieves desymmetrization by stereoselectively functionalizing open-shell radical species. This mini-review explores the research progress in this growing field, aiming to elucidate mechanistic scenarios related to stereochemical control. Additionally, it offers insights into the challenges and opportunities that lie ahead for further development.