Options for systemic therapy of uveitis including alternative therapies

IntroductionThe treatments for noninfectious uveitis (NIU) include topical steroids, local steroid injections, and systemic steroids or immunomodulatory agents. Over the last 20 years, there have been advancements in both conventional and alternative complementary therapies for uveitis. In this review, we will give an overview of the current conventional and alternative systemic treatments for NIU and discuss the possible risks and benefits to each.Areas CoveredConventional systemic therapies for NIU include corticosteroids, antimetabolites, biologics, calcineurin inhibitors, alkylating agents, janus kinase (JAK) inhibitors, and interferons. Alternative therapies include Ayurvedic medicine, berberine, glycosides, Traditional Chinese medicines, dietary changes, and vitamin supplementation.Expert OpinionThere are an expanding number of systemic treatments for NIU. Over the last 15 years, biologic agents in particular have expanded and improved treatment options for patients with NIU.