Mitochondrial Haplogroups and Weight Gain After Initiating ART in Patients With HIV

We studied the association of mitochondrial DNA (mtDNA) haplogroups with weight and body mass index (BMI) gain at 96 weeks in 1019 treatment-naive persons with HIV (PWH) who initiated first-line antiretroviral therapy (ART) since 2014. The mean increase in weight and BMI over the study period was 2.90 kg and 0.98 kg/m2, respectively. We found a significant adjusted association between the major UK mtDNA haplogroup and lower weight and BMI increase at 96 weeks after ART initiation. Our findings reveal a potential role for mitochondrial genetics in the complex phenomenon of weight gain after initial ART in PWH. We examined the association of mt-DNA haplogroups with weight/BMI gain 96 weeks after ART initiation in treatment-naive patients. A significant association was found between major UK mtDNA haplogroup and lower weight/BMI increase, highlighting mitochondrial genetics' role in posttreatment weight dynamics. Graphical Abstract