Analysis of the sensitization spectrum in patients with severe allergic diseases using the ImmunoCAP ISAC method

BACKGROUND: An important advance in modern allergology has been made by the introduction of allergenic molecules/components, including their detection by the ImmunoCAP ISAC method. This method is useful in patients with a complex spectrum of sensitization and severe forms of allergic diseases, where various predictors of severe course are actively searched for. AIMS: To evaluate the informativeness of component resolved diagnostic by ISAC ImmunoCAP method in patients with severe bronchial asthma (SBA) and severe atopic dermatitis (SAD MATERIALS AND METHODS: A single-center retrospective study was conducted from January to August 2023. 100 patients who were candidates for biologicals for SBA (63 patients) - group 1, SAD (20 patients) - group 2, or their combination (17 patients) - group 3 were included. Component restlved diagnostic was performed by ImmunoCAP ISAC method. Mathematical and statistical data processing was performed using Python3.10 programming language packages in IDE Visual Studio Code 1.76.1 (Universal). The following criteria were used: Student's, Gaims-Howell, Kraskell-Wallis, Dunn with Holm's correction. RESULTS: Polysensitization and high occurrence of food and fungal allergens were more frequently detected in