Figure S5 from Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia

Figure S5: Oxamate displays minimal toxicity to AML myeloblasts alone. AML myeloblasts were cultured for 72 hr with BETi (0.15 µM) and indicated lactate utilization inhibitors (AZD3965, UK5099, oxamate = 0.1 µM) and viability quantified using a fluorescent plate reader. Viability was quantified relative to cells treated with vehicle control. Each point represents the mean (technical duplicate) value obtained from cells from an individual experiment (n=3).