Evaluation of a hapten conjugate vaccine against the "zombie drug" xylazine

Xylazine has emerged as a primary adulterant in fentanyl, exacerbating the complexity of the opioid crisis. Yet, there is no approved drug that can reverse xylazine's pathophysiology. As a prelude to monoclonal antibodies being assessed as a viable therapeutic, a vaccine inquiry was conducted evaluating the immune response in reversing xylazine induced behavior effects. The first xylazine hapten conjugate vaccine is disclosed demonstrating how antibodies can blunt xylazine intoxication.