CODA (part 5): nuclear coordinate generation | HuBMAP | JHU-TMC v1

In this section, generate nuclear coordinates on thehigh-resolution H&E images through color deconvolution and identificationof two-dimensional intensity minimums in the hematoxylin channels of the images(corresponding to the dark blue nuclei). This calculation is done on thehigh-resolution tif images saved inside pth10x. Note on cell detection: It is important that the cellcoordinates are generated on unregistered images, as warping caused by theregistration process can cause inaccuracies in nuclear detection performed onthe registered images. Instead, detect coordinates on the unregistered images,then apply the registration transformations to the cell coordinates todetermine their positions in registered space.